Preheat oven to 400°F. In a deep baking dish, toss cherry tomatoes and mushrooms with olive oil. Roast for 20 minutes until softened and slightly blistered.
Remove from oven and stir in dry orzo, pesto, 2 cups of chicken broth, and all the spices: garlic powder, onion powder, pepper, paprika, and cayenne. Mix well to combine.
Return to the oven and bake for another 20 minutes.
Pour in the remaining ½ cup of broth, stir everything again, and bake for another 10 minutes.
Finally, stir in the shredded cheese and bake for 5 more minutes until everything is creamy and melted.
Give it a final stir and serve hot. Add your choice of protein on top or on the side—grilled chicken, shrimp, or even crispy tofu all work beautifully.